6-Chloro-N,N-dimethylnicotinamide → 6-({3-(Aminocarbonyl)-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)-N,N-dimethylnicotinamide

HRID 2138914Notes

Reaction equation

HRID 2138914 reaction equation
[Cl:21][c:22]1[n:23][cH:24][c:25]([C:26](=[O:27])[N:28]([CH3:29])[CH3:30])[cH:31][cH:32]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:22]1[n:23][cH:24][c:25]([C:26](=[O:27])[N:28]([CH3:29])[CH3:30])[cH:31][cH:32]1

Participants

3

Reactant 2

HCID 123642316-Chloro-N,N-dimethylnicotinamideHCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595259096-({3-(Aminocarbonyl)-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)-N,N-dimethylnicotinamide

Sources & evidence

ORD record
ord-51087757ab7945a3bcee001b6a01ad5d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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