1-Oxa-3,8-diazaspiro(4.5)decan 2-one → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide
Reaction equation
[F:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([C:26](=[O:27])[NH2:28])[c:15]([NH:17][c:18]3[n:19][c:20]([CH:24]=[O:25])[cH:21][cH:22][cH:23]3)[s:16]2)[cH:4][cH:5][c:6]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:7]1.[O:29]1[C:30](=[O:39])[NH:31][CH2:32][C:33]12[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]2>>[F:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([C:26](=[O:27])[NH2:28])[c:15]([NH:17][c:18]3[n:19][c:20]([CH2:24][N:36]4[CH2:35][CH2:34][C:33]5([O:29][C:30](=[O:39])[NH:31][CH2:32]5)[CH2:38][CH2:37]4)[cH:21][cH:22][cH:23]3)[s:16]2)[cH:4][cH:5][c:6]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:7]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-4f8acd1e6d88400796edb9f0c5dd07a9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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