(2-Isopropylthiazol-4-yl)methanamine → 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((2-isopropylthiazol-4-yl)methyl)-4-methylthiazole-5-carboxamide

HRID 2139950Notes

Reaction equation

HRID 2139950 reaction equation
[CH:45]([CH3:46])([CH3:47])[c:48]1[s:49][cH:50][c:51]([CH2:53][NH2:54])[n:52]1.[F:1][C:2]1([F:3])[CH2:4][CH:5]1[CH2:6][N:7]1[CH2:8][CH2:9][N:10]([c:11]2[s:12][c:13]([C:14]([OH:15])=[O:16])[c:17]([CH3:18])[n:19]2)[C:20]1=[O:21].[F:22][c:23]1[cH:24][cH:25][c:26]([CH2:27][N:28]2[C:29](=[O:42])[N:30]([c:33]3[s:34][c:35]([C:39](=[O:40])[OH:41])[c:36]([CH3:38])[n:37]3)[CH2:31][CH2:32]2)[cH:43][cH:44]1>>[F:22][c:23]1[cH:24][cH:25][c:26]([CH2:27][N:28]2[C:29](=[O:42])[N:30]([c:33]3[s:34][c:35]([C:39](=[O:40])[NH:54][CH2:53][c:51]4[cH:50][s:49][c:48]([CH:45]([CH3:46])[CH3:47])[n:52]4)[c:36]([CH3:38])[n:37]3)[CH2:31][CH2:32]2)[cH:43][cH:44]1

Participants

4

Reactant 3

HCID 16427107(2-Isopropylthiazol-4-yl)methanamineHCID 579197992-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acidHCID 579198122-(3-((2,2-Difluorocyclopropyl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

Product 1

HCID 579199532-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((2-isopropylthiazol-4-yl)methyl)-4-methylthiazole-5-carboxamide

Sources & evidence

ORD record
ord-7c4d15d273354d4ebca9faecf38c9f48
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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