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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2139992Generated: October 27, 2026

Tetrahydrofuran → 6-(4-(4-amino-3-hydroxyazepan-1-yl)furo[3,2-d]pyrimidin-2-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one

https://huagongshe.com/reaction/2139992

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantTetrabutylammoniumHCID 16028—
ReactantFluoride IonHCID 28179—
Reactant6-Amino-2,2-dimethyl-2H-benzo[B][1,4]oxazin-3(4H)-oneHCID 13665496—
Reactant2,4-Dichlorofuro[3,2-D]pyrimidineHCID 45789968—
Reactant6-(4-(4-amino-3-(tert-butyldimethylsilyloxy)azepan-1-yl)furo[3,2-d]pyrimidin-2-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-oneHCID 68751628—
Product6-(4-(4-amino-3-hydroxyazepan-1-yl)furo[3,2-d]pyrimidin-2-ylamino)-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-oneHCID 68753132—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (4/10)
ORD IDord-1e823bb32ca5466fbe69eb7dccd80cbe
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (4/10)