3,4-Difluoroaniline → 1-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

HRID 2140064Notes

Reaction equation

HRID 2140064 reaction equation
[F:15][c:16]1[cH:17][c:18]([NH2:19])[cH:20][cH:21][c:22]1[F:23].[F:24][c:25]1[cH:26][cH:27][c:28]([NH:29][CH:30]2[CH2:31][CH2:32][N:33]([C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[CH2:41][CH2:42]2)[cH:43][cH:44]1.[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[CH:2]1([NH:19][c:18]2[cH:17][c:16]([F:15])[c:22]([F:23])[cH:21][cH:20]2)[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 774693,4-DifluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 16413902tert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylate

Product 1

HCID 225580331-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

Sources & evidence

ORD record
ord-980204442f4545a1b7c5ee836939d468
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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