6-(Morpholino)pyridin-3-amine → 1-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(6-morpholin-4-yl-pyridin-3-yl)-urea

HRID 2140238Notes

Reaction equation

HRID 2140238 reaction equation
[Cl:25][c:26]1[c:27]([S:39](=[O:40])(=[O:41])[CH3:42])[cH:28][c:29](-[c:32]2[c:33]([CH3:38])[n:34][c:35]([NH2:37])[s:36]2)[cH:30][cH:31]1.[F:1][c:2]1[cH:3][c:4](-[c:5]2[s:6][c:7]([NH:8][C:18]([NH:9][CH2:10][CH2:11][OH:12])=[O:19])[n:13][c:14]2[CH3:15])[cH:16][cH:17][c:20]1[S:21]([CH3:22])(=[O:23])=[O:24].[O:43]1[CH2:44][CH2:45][N:46]([c:49]2[cH:50][cH:51][c:52]([NH2:55])[cH:53][n:54]2)[CH2:47][CH2:48]1>>[C:18](=[O:19])([NH:37][c:35]1[n:34][c:33]([CH3:38])[c:32](-[c:29]2[cH:28][c:27]([S:39](=[O:40])(=[O:41])[CH3:42])[c:26]([Cl:25])[cH:31][cH:30]2)[s:36]1)[NH:55][c:52]1[cH:51][cH:50][c:49]([N:46]2[CH2:45][CH2:44][O:43][CH2:48][CH2:47]2)[n:54][cH:53]1

Participants

4

Reactant 3

HCID 1040596-(Morpholino)pyridin-3-amineHCID 578311165-[4-Chloro-3-(methylsulfonyl)phenyl]-4-methyl-1,3-thiazol-2-amineHCID 865984211-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(2-hydroxy-ethyl)-urea

Product 1

HCID 865984301-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-(6-morpholin-4-yl-pyridin-3-yl)-urea

Sources & evidence

ORD record
ord-79d7fc9982db4a519b8752187f77f7e2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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