5-Bromopyridine-2-carboxamide → 5-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridine-2-carboxylic acid amide

HRID 2140555Notes

Reaction equation

HRID 2140555 reaction equation
[Br:25][c:26]1[cH:27][cH:28][c:29]([C:32](=[O:33])[NH2:34])[n:30][cH:31]1.[C:1](#[CH:2])[c:3]1[cH:4][n:5][n:6]2[c:7]1[n:8][c:9](-[c:15]1[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]1)[cH:10][c:11]2[CH:12]([F:13])[F:14]>>[C:1](#[C:2][c:26]1[cH:27][cH:28][c:29]([C:32](=[O:33])[NH2:34])[n:30][cH:31]1)[c:3]1[cH:4][n:5][n:6]2[c:7]1[n:8][c:9](-[c:15]1[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]1)[cH:10][c:11]2[CH:12]([F:13])[F:14]

Participants

3

Reactant 2

HCID 7351515-Bromopyridine-2-carboxamideHCID 866080343-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670009965-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridine-2-carboxylic acid amide

Sources & evidence

ORD record
ord-996062b764064b1fbae5576ec64879c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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