2-Chloro-4-methylpyrimidine → 2-Propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]-2,4-difluorophenyl}carbamate

HRID 2141047Notes

Reaction equation

HRID 2141047 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH2:8][C:9]([c:10]2[cH:11][c:12]([NH:13][C:14](=[O:15])[O:16][CH2:17][CH:18]=[CH2:19])[cH:20][cH:21][cH:22]2)=[O:23])[n:7]1.[Cl:43][c:44]1[n:45][c:46]([CH3:47])[cH:48][cH:49][n:50]1.[F:24][c:25]1[c:26]([C:27]([O:29][CH3:28])=[O:30])[c:31]([F:42])[cH:32][cH:33][c:34]1[NH:35][C:36](=[O:37])[O:38][CH2:39][CH:40]=[CH2:41]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH2:8][C:27]([c:26]2[c:25]([F:24])[c:34]([NH:35][C:36](=[O:37])[O:38][CH2:39][CH:40]=[CH2:41])[cH:33][cH:32][c:31]2[F:42])=[O:29])[n:7]1

Participants

4

Reactant 3

HCID 116296072-Chloro-4-methylpyrimidineHCID 57989916Methyl 2,6-difluoro-3-{[(2-propen-1-yloxy)carbonyl]amino}benzoateHCID 579899812-Propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}carbamate

Product 1

HCID 579899062-Propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]-2,4-difluorophenyl}carbamate

Sources & evidence

ORD record
ord-6bb92c404e2e481a8fc109d846a5f122
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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