{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → {1-[4-(8-Difluoromethoxy-4-oxo-2-phenyl-4H-pyrano[2,3-c]pyridin-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1([c:12]2[cH:13][cH:14][c:15](-[c:18]3[c:19](=[O:20])[c:21]4[c:22]([cH:23][cH:24][c:25]([F:26])[cH:27]4)[o:28][c:29]3-[c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[cH:16][cH:17]2)[CH2:9][CH2:10][CH2:11]1)=[O:36].[F:37][CH:38]([O:39][c:40]1[n:41][cH:42][cH:43][c:44]2[c:45]1[o:46][c:47](-[c:52]1[cH:53][cH:54][cH:55][cH:56][cH:57]1)[c:48]([I:51])[c:49]2=[O:50])[F:58]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1([c:12]2[cH:13][cH:14][c:15](-[c:48]3[c:47](-[c:52]4[cH:53][cH:54][cH:55][cH:56][cH:57]4)[o:46][c:45]4[c:40]([O:39][CH:38]([F:37])[F:58])[n:41][cH:42][cH:43][c:44]4[c:49]3=[O:50])[cH:16][cH:17]2)[CH2:9][CH2:10][CH2:11]1)=[O:36]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-a31ee13a58ca41948329849faac5eb25
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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