2-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester → 1-(2-Chloro-3,6-difluorobenzyl)-7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

HRID 2141454Notes

Reaction equation

HRID 2141454 reaction equation
[CH3:28][N:29]1[CH2:30][CH2:31][N:32]([c:35]2[cH:36][c:37]([B:38]3[O:39][C:40]([CH3:41])([CH3:42])[C:43]([CH3:44])([CH3:45])[O:46]3)[cH:47][cH:48][n:49]2)[CH2:33][CH2:34]1.[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:15]4[cH:16][c:17]([Cl:21])[n:18][cH:19][cH:20]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[c:22]([F:27])[cH:23][cH:24][c:25]1[F:26]>>[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:15]4[cH:16][c:17]([N:32]5[CH2:31][CH2:30][N:29]([CH3:28])[CH2:34][CH2:33]5)[n:18][cH:19][cH:20]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[c:22]([F:27])[cH:23][cH:24][c:25]1[F:26]

Participants

3

Reactant 2

HCID 27695372-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol esterHCID 578858211-(2-Chloro-3,6-difluorobenzyl)-7-(2-chloropyridin-4-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Product 1

HCID 578858911-(2-Chloro-3,6-difluorobenzyl)-7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Sources & evidence

ORD record
ord-722b43f00e56426cb4da72dcf6f60b78
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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