Dimethyl Sulfoxide → Tert-butyl 2-[6-[(3-propan-2-yloxyphenyl)carbamoyl]pyrazin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

HRID 214210Notes

Reaction equation

HRID 214210 reaction equation
[CH2:21]1[N:22]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:23][CH:24]2[CH:25]1[CH2:26][NH:27][CH2:28]2.[CH3:42][S:43]([CH3:44])=[O:45].[Cl:1][c:2]1[cH:3][n:4][cH:5][c:6]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13]([O:17][CH:18]([CH3:19])[CH3:20])[cH:14][cH:15][cH:16]2)[n:7]1.[Na+:36].[Na+:37].[O-:38][C:39](=[O:40])[O-:41]>>[c:2]1([N:27]2[CH2:26][CH:25]3[CH2:21][N:22]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:23][CH:24]3[CH2:28]2)[cH:3][n:4][cH:5][c:6]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13]([O:17][CH:18]([CH3:19])[CH3:20])[cH:14][cH:15][cH:16]2)[n:7]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 4142526Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylateHCID 848200206-Chloro-N-(3-isopropoxyphenyl)pyrazine-2-carboxamide

Product 1

HCID 67265481Tert-butyl 2-[6-[(3-propan-2-yloxyphenyl)carbamoyl]pyrazin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

Sources & evidence

ORD record
ord-671aaa53cd90402da9155269a4412eef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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