Pyridine → Tert-butyl 4-(2-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-5-methylpyrimidin-4-yl)benzoate

HRID 2142988Notes

Reaction equation

HRID 2142988 reaction equation
[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[Cl:16])[CH2:12][CH2:13]3)[cH:10]2)[O:6]1.[NH2:18][c:19]1[n:20][cH:21][c:22]([CH3:38])[c:23](-[c:25]2[cH:26][cH:27][c:28]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37]2)[n:24]1.[cH:39]1[cH:40][cH:41][n:42][cH:43][cH:44]1>>[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[NH:18][c:19]4[n:20][cH:21][c:22]([CH3:38])[c:23](-[c:25]5[cH:26][cH:27][c:28]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37]5)[n:24]4)[CH2:12][CH2:13]3)[cH:10]2)[O:6]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 575168501-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chlorideHCID 57856165Tert-butyl 4-(2-amino-5-methylpyrimidin-4-yl)benzoate

Product 1

HCID 57856181Tert-butyl 4-(2-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-5-methylpyrimidin-4-yl)benzoate

Sources & evidence

ORD record
ord-5e10bc2d10fc41ce923411b6add56b2c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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