Sodium ion → Tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate

HRID 2143409Notes

Reaction equation

HRID 2143409 reaction equation
[C:65](=[O:66])([O-:67])[O-:68].[CH3:1][Si:2]([CH2:3][CH2:4][O:5][CH2:6][N:7]([c:8]1[cH:9][c:10]([CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]2)[n:11][c:12]2[n:13]1[n:14][cH:15][c:16]2[I:17])[CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])([CH3:39])[CH3:40].[CH3:71][O:72][CH2:73][CH2:74][O:75][CH3:76].[Cl:62][CH2:63][Cl:64].[Na+:69].[Na+:70].[c:41]1(-[c:47]2[n:48][cH:49][c:50]([B:53]3[O:54][C:55]([CH3:56])([CH3:57])[C:58]([CH3:59])([CH3:60])[O:61]3)[cH:51][cH:52]2)[cH:42][cH:43][cH:44][cH:45][cH:46]1>>[CH3:1][Si:2]([CH2:3][CH2:4][O:5][CH2:6][N:7]([c:8]1[cH:9][c:10]([CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]2)[n:11][c:12]2[n:13]1[n:14][cH:15][c:16]2-[c:50]1[cH:49][n:48][c:47](-[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:52][cH:51]1)[CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])([CH3:39])[CH3:40]

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6344DichloromethaneHCID 80711,2-DimethoxyethaneHCID 19660Carbonate IonHCID 457865262-Phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 66584511Tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate

Product 1

HCID 66584899Tert-butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-3e383b623bfa4a4d987aa15ac5437ba6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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