Acetonitrile → (RS)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(3-fluoro-4-methyl-phenylamino)-butan-2-ol

HRID 2143626Notes

Reaction equation

HRID 2143626 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][CH:9]1[O:10][CH2:11]1)([CH3:12])[CH3:13].[CH3:23][C:24]#[N:25].[F:14][c:15]1[cH:16][c:17]([NH2:18])[cH:19][cH:20][c:21]1[CH3:22]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][CH:9]([OH:10])[CH2:11][NH:18][c:17]1[cH:16][c:15]([F:14])[c:21]([CH3:22])[cH:20][cH:19]1)([CH3:12])[CH3:13]

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 99573-Fluoro-4-methylanilineHCID 11030897(R)-tert-butyldimethyl(2-(oxiran-2-yl)ethoxy)silane

Product 1

HCID 66954684(RS)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(3-fluoro-4-methyl-phenylamino)-butan-2-ol

Sources & evidence

ORD record
ord-c6224e4f8a194f4ead1a58a5f1a411a9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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