5-(Cyclopropylmethoxy)pyridine-2-carboxylic acid → N-[3-(2-amino-4-methyl-4a,5,7,7a-tetrahydrofuro[3,4-e][1,3]oxazin-4-yl)-4-fluorophenyl]-5-(cyclopropylmethoxy)pyridine-2-carboxamide

HRID 2143709Notes

Reaction equation

HRID 2143709 reaction equation
[CH:20]1([CH2:23][O:24][c:25]2[cH:26][cH:27][c:28]([C:31](=[O:32])[OH:33])[n:29][cH:30]2)[CH2:21][CH2:22]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]2([CH3:18])[N:9]=[C:10]([NH2:17])[O:11][CH:12]3[CH2:13][O:14][CH2:15][CH:16]23)[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]2([CH3:18])[N:9]=[C:10]([NH2:17])[O:11][CH:12]3[CH2:13][O:14][CH2:15][CH:16]23)[cH:7]1)[C:31]([c:28]1[cH:27][cH:26][c:25]([O:24][CH2:23][CH:20]2[CH2:21][CH2:22]2)[cH:30][n:29]1)=[O:32]

Participants

3

Reactant 2

HCID 666918955-(Cyclopropylmethoxy)pyridine-2-carboxylic acidHCID 178421628HCID 178421628, compound

Product 1

HCID 72663611N-[3-(2-amino-4-methyl-4a,5,7,7a-tetrahydrofuro[3,4-e][1,3]oxazin-4-yl)-4-fluorophenyl]-5-(cyclopropylmethoxy)pyridine-2-carboxamide

Sources & evidence

ORD record
ord-57e95839cf504323925ad7af40b161b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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