Acetone → 1-O-tert-butyl 2-O-[2-[9-[4-(methoxymethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]oxy-8-oxo-5,9,10,11-tetrahydronaphtho[2,3-c]isochromen-3-yl]-2-oxoethyl] 5-methylpyrrolidine-1,2-dicarboxylate

HRID 214393Notes

Reaction equation

HRID 214393 reaction equation
[C:40]([CH3:41])([CH3:42])([CH3:43])[O:44][C:45](=[O:46])[N:47]1[CH:48]([C:55](=[O:56])[OH:57])[CH2:49][CH:50]([CH2:52][O:53][CH3:54])[CH2:51]1.[C:58](=[O:59])([O-:60])[O-:61].[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([C:14](=[O:15])[O:16][CH2:17][C:18](=[O:19])[c:20]2[cH:21][cH:22][c:23]3[c:24]([cH:39]2)[CH2:25][O:26][c:27]2[cH:28][c:29]4[c:30]([cH:31][c:32]2-3)[CH2:33][CH2:34][CH:35]([Br:38])[C:36]4=[O:37])[N:6]1[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13].[CH3:64][C:65](=[O:66])[CH3:67].[Cl:68][CH2:69][Cl:70].[Cs+:62].[Cs+:63]>>[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([C:14](=[O:15])[O:16][CH2:17][C:18](=[O:19])[c:20]2[cH:21][cH:22][c:23]3[c:24]([cH:39]2)[CH2:25][O:26][c:27]2[cH:28][c:29]4[c:30]([cH:31][c:32]2-3)[CH2:33][CH2:34][CH:35]([O:57][C:55]([CH:48]2[N:47]([C:45]([O:44][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:46])[CH2:51][CH:50]([CH2:52][O:53][CH3:54])[CH2:49]2)=[O:56])[C:36]4=[O:37])[N:6]1[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13]

Participants

7

Reactant 6

HCID 180AcetoneHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 696720621-(tert-Butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acidHCID 776907442-O-[2-(9-bromo-8-oxo-5,9,10,11-tetrahydronaphtho[2,3-c]isochromen-3-yl)-2-oxoethyl] 1-O-tert-butyl 5-methylpyrrolidine-1,2-dicarboxylate

Product 1

HCID 773355431-O-tert-butyl 2-O-[2-[9-[4-(methoxymethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]oxy-8-oxo-5,9,10,11-tetrahydronaphtho[2,3-c]isochromen-3-yl]-2-oxoethyl] 5-methylpyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-cc5465946d3540398359ef93646c5be1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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