Methanol → Methyl trans-3-((3-fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)amino)cyclobutanecarboxylate

HRID 2144479Notes

Reaction equation

HRID 2144479 reaction equation
[CH3:38][OH:39].[F:1][c:2]1[cH:3][c:4]([NH:26][CH:27]2[CH2:28][CH:29]([C:31](=[O:32])[OH:33])[CH2:30]2)[cH:5][cH:6][c:7]1-[c:8]1[s:9][c:10]2[n:11][c:12]([C:17]3([c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)[CH2:18][CH2:19]3)[cH:13][cH:14][c:15]2[n:16]1.[S:34]([Cl:35])([Cl:36])=[O:37]>>[F:1][c:2]1[cH:3][c:4]([NH:26][CH:27]2[CH2:28][CH:29]([C:31](=[O:32])[O:33][CH3:38])[CH2:30]2)[cH:5][cH:6][c:7]1-[c:8]1[s:9][c:10]2[n:11][c:12]([C:17]3([c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)[CH2:18][CH2:19]3)[cH:13][cH:14][c:15]2[n:16]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 591748373-(3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-phenylamino)-cyclobutanecarboxylic acid

Product 1

HCID 67111958Methyl trans-3-((3-fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)amino)cyclobutanecarboxylate

Sources & evidence

ORD record
ord-1cb6b03a7df64ba7b4d2a168d7e7450a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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