5-chloro-6-fluoro-1H-indole-7-carboxylic acid → 5-Chloro-6-fluoro-1H-indole-7-carboxylic acid [4-(isopropyl-dimethyl-silanyl)-benzyl]-[2-(3-trifluoromethyl-phenyl)-ethyl]-amide
Reaction equation
[CH:15]([CH3:16])([CH3:17])[Si:18]([c:19]1[cH:20][cH:21][c:22]([CH2:23][NH:24][CH2:25][CH2:26][c:27]2[cH:28][c:29]([C:33]([F:34])([F:35])[F:36])[cH:30][cH:31][cH:32]2)[cH:37][cH:38]1)([CH3:39])[CH3:40].[Cl:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][nH:7][c:8]2[c:9]([C:12](=[O:13])[OH:14])[c:10]1[F:11]>>[Cl:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][nH:7][c:8]2[c:9]([C:12](=[O:14])[N:24]([CH2:23][c:22]2[cH:21][cH:20][c:19]([Si:18]([CH:15]([CH3:16])[CH3:17])([CH3:39])[CH3:40])[cH:38][cH:37]2)[CH2:25][CH2:26][c:27]2[cH:28][c:29]([C:33]([F:34])([F:35])[F:36])[cH:30][cH:31][cH:32]2)[c:10]1[F:11]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-7ff8d22210e24730a59fe4f0908ea31c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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