Malonic Acid → 2-Chloro-4,6-dimethoxyquinoline

HRID 214517Notes

Reaction equation

HRID 214517 reaction equation
[CH3:15][O:16][c:17]1[cH:18][cH:19][c:20]([NH2:21])[cH:22][cH:23]1.[CH3:31][O-:32].[CH3:34][OH:35].[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([O:13][CH3:14])[cH:8][c:9]2[c:10]([Cl:12])[cH:11]1.[Na+:33].[OH2:36].[OH:24][C:25]([CH2:26][C:27](=[O:28])[OH:29])=[O:30]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([O:13][CH3:14])[cH:8][c:9]2[c:10]([O:16][CH3:15])[cH:11]1

Participants

8

Reactant 7

HCID 867Malonic AcidHCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 7732P-AnisidineHCID 9483562,4-Dichloro-6-methoxyquinolineHCID 3826051Methoxide

Product 1

HCID 579701022-Chloro-4,6-dimethoxyquinoline

Sources & evidence

ORD record
ord-5dfc8f0f9ea94f1c876d8cc1ea63efaf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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