Dichloromethane → N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-(1-trityloxypropan-2-yloxy)pyrimidin-4-yl]pyridine-4-sulfonamide

HRID 2145694Notes

Reaction equation

HRID 2145694 reaction equation
[C:11](=[O:12])([O-:13])[O-:14].[Cl:17][c:18]1[n:19][c:20]([S:48][CH2:49][c:50]2[c:51]([F:57])[c:52]([F:56])[cH:53][cH:54][cH:55]2)[n:21][c:22]([O:24][CH:25]([CH2:26][O:27][C:28]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[CH3:47])[cH:23]1.[Cl:64][CH2:65][Cl:66].[Cs+:15].[Cs+:16].[O:105]=[C:106]([CH:107]=[CH:108][c:109]1[cH:110][cH:111][cH:112][cH:113][cH:114]1)[CH:115]=[CH:116][c:117]1[cH:118][cH:119][cH:120][cH:121][cH:122]1.[O:58]1[CH2:59][CH2:60][O:61][CH2:62][CH2:63]1.[O:69]=[C:70]([CH:71]=[CH:72][c:73]1[cH:74][cH:75][cH:76][cH:77][cH:78]1)[CH:79]=[CH:80][c:81]1[cH:82][cH:83][cH:84][cH:85][cH:86]1.[O:87]=[C:88]([CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1)[CH:97]=[CH:98][c:99]1[cH:100][cH:101][cH:102][cH:103][cH:104]1.[Pd:67].[Pd:68].[n:1]1[cH:2][cH:3][c:4]([S:7](=[O:8])(=[O:9])[NH2:10])[cH:5][cH:6]1>>[n:1]1[cH:2][cH:3][c:4]([S:7](=[O:8])(=[O:9])[NH:10][c:18]2[n:19][c:20]([S:48][CH2:49][c:50]3[c:51]([F:57])[c:52]([F:56])[cH:53][cH:54][cH:55]3)[n:21][c:22]([O:24][CH:25]([CH2:26][O:27][C:28]([c:29]3[cH:30][cH:31][cH:32][cH:33][cH:34]3)([c:35]3[cH:36][cH:37][cH:38][cH:39][cH:40]3)[c:41]3[cH:42][cH:43][cH:44][cH:45][cH:46]3)[CH3:47])[cH:23]2)[cH:5][cH:6]1

Participants

9

Reactant 8

HCID 6344DichloromethaneHCID 19660Carbonate IonHCID 23938Palladium2×HCID 312751,4-DioxaneHCID 95417Dibenzylidene acetone3×HCID 104967Cesium cation2×HCID 12383449Pyridine-4-sulfonamideHCID 178458992HCID 178458992, compound

Product 1

HCID 178458996N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-(1-trityloxypropan-2-yloxy)pyrimidin-4-yl]pyridine-4-sulfonamide

Sources & evidence

ORD record
ord-16a063927b6a4f5b9a0c867e03a5420d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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