2-[4-(4-Amino-2-methoxy-phenyl)-piperidin-1-yl]-acetamide → 2-(4-{2-Methoxy-4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperidin-1-yl)-acetamide

HRID 214601Notes

Reaction equation

HRID 214601 reaction equation
[CH3:1][O:2][c:3]1[c:4](-[c:9]2[cH:10][cH:11][c:12]3[cH:13][n:14][c:15]([O:18][S:19]([C:20]([F:21])([F:22])[F:23])(=[O:24])=[O:25])[n:16][n:17]23)[cH:5][cH:6][cH:7][cH:8]1.[NH2:26][c:27]1[cH:28][c:29]([O:43][CH3:44])[c:30]([CH:33]2[CH2:34][CH2:35][N:36]([CH2:39][C:40](=[O:41])[NH2:42])[CH2:37][CH2:38]2)[cH:31][cH:32]1>>[CH3:1][O:2][c:3]1[c:4](-[c:9]2[cH:10][cH:11][c:12]3[cH:13][n:14][c:15]([NH:26][c:27]4[cH:28][c:29]([O:43][CH3:44])[c:30]([CH:33]5[CH2:34][CH2:35][N:36]([CH2:39][C:40](=[O:41])[NH2:42])[CH2:37][CH2:38]5)[cH:31][cH:32]4)[n:16][n:17]23)[cH:5][cH:6][cH:7][cH:8]1

Participants

3

Reactant 2

HCID 667119832-[4-(4-Amino-2-methoxy-phenyl)-piperidin-1-yl]-acetamideHCID 86661678Trifluoro-methanesulfonic acid 7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl ester

Product 1

HCID 667119392-(4-{2-Methoxy-4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperidin-1-yl)-acetamide

Sources & evidence

ORD record
ord-e2839bd1ca1244e1a448c5bf83a99dc0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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