Dichloromethane → N-(7'-bromo-4'-fluoro-2'-methoxy-5,6-dihydrospiro[[1,3]thiazine-4,9'-xanthen]-2-yl)benzamide

HRID 2146296Notes

Reaction equation

HRID 2146296 reaction equation
[Br:9][c:10]1[cH:11][cH:12][c:13]2[c:22]([cH:23]1)[C:21]([CH2:24][CH2:25][OH:26])([NH:27][C:28](=[S:29])[NH:30][C:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)=[O:38])[c:20]1[c:15]([c:16]([F:41])[cH:17][c:18]([O:39][CH3:40])[cH:19]1)[O:14]2.[Cl:1][C:2]([N:3]([CH3:4])[CH3:5])=[C:6]([CH3:7])[CH3:8].[Cl:42][CH2:43][Cl:44]>>[Br:9][c:10]1[cH:11][cH:12][c:13]2[c:22]([cH:23]1)[C:21]1([c:20]3[c:15]([c:16]([F:41])[cH:17][c:18]([O:39][CH3:40])[cH:19]3)[O:14]2)[CH2:24][CH2:25][S:29][C:28]([NH:30][C:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)=[O:38])=[N:27]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 86658378N-((7-bromo-4-fluoro-9-(2-hydroxyethyl)-2-methoxy-9H-xanthen-9-yl)carbamothioyl)benzamide

Product 1

HCID 67436735N-(7'-bromo-4'-fluoro-2'-methoxy-5,6-dihydrospiro[[1,3]thiazine-4,9'-xanthen]-2-yl)benzamide

Sources & evidence

ORD record
ord-f93236111ff848bab148fe2b47471e19
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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