Pyridine → 6-(Chloromethyl)-N-[6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide

HRID 2146303Notes

Reaction equation

HRID 2146303 reaction equation
[Cl:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][c:7]([C:9](=[O:10])[Cl:11])[n:8]1.[Cl:49][CH2:50][Cl:51].[NH2:12][c:13]1[c:14]2[cH:15][n:16][n:17]([S:34](=[O:35])(=[O:36])[c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[c:18]2[cH:19][c:20](-[c:22]2[cH:23][c:24]([NH:29][S:30](=[O:31])(=[O:32])[CH3:33])[c:25]([Cl:28])[n:26][cH:27]2)[cH:21]1.[cH:43]1[cH:44][cH:45][n:46][cH:47][cH:48]1>>[Cl:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][c:7]([C:9](=[O:10])[NH:12][c:13]2[c:14]3[cH:15][n:16][n:17]([S:34](=[O:35])(=[O:36])[c:37]4[cH:38][cH:39][cH:40][cH:41][cH:42]4)[c:18]3[cH:19][c:20](-[c:22]3[cH:23][c:24]([NH:29][S:30](=[O:31])(=[O:32])[CH3:33])[c:25]([Cl:28])[n:26][cH:27]3)[cH:21]2)[n:8]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 58255829N-{5-[4-Amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamideHCID 866533026-(Chloromethyl)-2-pyridinecarbonyl chloride

Product 1

HCID 582558416-(Chloromethyl)-N-[6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide

Sources & evidence

ORD record
ord-24ac2383f0ed40a7ac0b85c1e23e71da
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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