2-Amino-5-bromopyridine-3-carbonitrile → 2-Amino-5-[7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-nicotinonitrile

HRID 2147266Notes

Reaction equation

HRID 2147266 reaction equation
[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[CH:13])[F:24].[NH2:25][c:26]1[c:27]([C:28]#[N:29])[cH:30][c:31]([Br:34])[cH:32][n:33]1>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[C:13][c:31]1[cH:30][c:27]([C:28]#[N:29])[c:26]([NH2:25])[n:33][cH:32]1)[F:24]

Participants

3

Reactant 2

HCID 242291992-Amino-5-bromopyridine-3-carbonitrileHCID 866080343-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670008262-Amino-5-[7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-nicotinonitrile

Sources & evidence

ORD record
ord-dee64646170a446683b754248834c1e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…