Dichloromethane → 1-tert-Butyl-3-cyclobutyl-5-(3,5-dichloro-phenyl)-1,7-dihydro-pyrazolo[3,4-b]pyridin-6-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([nH:6][c:7]1=[O:8])[n:9]([C:16]([CH3:17])([CH3:18])[CH3:19])[n:10][c:11]2[CH:12]1[CH2:13][CH2:14][CH2:15]1.[CH2:33]([CH2:34][O:35][CH3:36])[O:37][CH3:38].[Cl:20][c:21]1[cH:22][c:23]([B:28]([OH:29])[OH:30])[cH:24][c:25]([Cl:27])[cH:26]1.[Cl:39][CH2:40][Cl:41].[Cs+:32].[F-:31].[cH:42]1[cH:43][cH:44][c:45]([P:46]([Pd:47]([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)([P:67]([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[P:86]([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)([c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)[c:111]2[cH:112][cH:113][cH:114][cH:115][cH:116]2)[cH:117][cH:118]1>>[c:2]1(-[c:23]2[cH:22][c:21]([Cl:20])[cH:26][c:25]([Cl:27])[cH:24]2)[cH:3][c:4]2[c:5]([nH:6][c:7]1=[O:8])[n:9]([C:16]([CH3:17])([CH3:18])[CH3:19])[n:10][c:11]2[CH:12]1[CH2:13][CH2:14][CH2:15]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-d493d887da2443a6860cfd30dba159e9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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