8-Methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylamine → 5-Chloro-N(4)-(4-dimethylamino-2-methoxy-phenyl)-N(2)-[8-methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-pyrimidine-2,4-diamine

HRID 214830Notes

Reaction equation

HRID 214830 reaction equation
[CH3:21][O:22][c:23]1[c:24]([NH2:42])[cH:25][c:26]2[c:27]([cH:41]1)[CH2:28][CH2:29][N:30]([CH2:33][CH2:34][N:35]1[CH2:36][CH2:37][O:38][CH2:39][CH2:40]1)[CH2:31][CH2:32]2.[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:20])[c:6]([NH:8][c:9]2[c:10]([O:18][CH3:19])[cH:11][c:12]([N:15]([CH3:16])[CH3:17])[cH:13][cH:14]2)[n:7]1>>[c:2]1([NH:42][c:24]2[c:23]([O:22][CH3:21])[cH:41][c:27]3[c:26]([cH:25]2)[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][N:35]2[CH2:36][CH2:37][O:38][CH2:39][CH2:40]2)[CH2:29][CH2:28]3)[n:3][cH:4][c:5]([Cl:20])[c:6]([NH:8][c:9]2[c:10]([O:18][CH3:19])[cH:11][c:12]([N:15]([CH3:16])[CH3:17])[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 672641368-Methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylamineHCID 86634017N(1)-(2,5-Dichloro-pyrimidin-4-yl)-2-methoxy-N(4),N(4)-dimethyl-benzene-1,4-diamine

Product 1

HCID 672636955-Chloro-N(4)-(4-dimethylamino-2-methoxy-phenyl)-N(2)-[8-methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-93dd0476f8d34827832b8402e203da47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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