3-Pyridinemethanamine → 2-[3-[(4-fluorophenyl)methyl]-5-methyl-2-oxoimidazolidin-1-yl]-4-methyl-N-[(5-methyl-1,2-oxazol-3-yl)methyl]-1,3-thiazole-5-carboxamide

HRID 2148494Notes

Reaction equation

HRID 2148494 reaction equation
[CH3:9][c:10]1[cH:11][c:12]([CH2:15][NH2:16])[n:13][o:14]1.[F:17][c:18]1[cH:19][cH:20][c:21]([CH2:22][N:23]2[CH:24]([CH3:25])[CH2:26][N:27]([c:28]3[s:29][c:30]([C:31]([OH:32])=[O:33])[c:34]([CH3:35])[n:36]3)[C:37]2=[O:38])[cH:39][cH:40]1.[F:41][c:42]1[cH:43][cH:44][c:45]([CH2:46][N:47]2[C:48](=[O:62])[N:49]([c:53]3[s:54][c:55]([C:59](=[O:60])[OH:61])[c:56]([CH3:58])[n:57]3)[CH:50]([CH3:52])[CH2:51]2)[cH:63][cH:64]1.[n:1]1[cH:2][cH:3][cH:4][c:5]([CH2:6][NH2:7])[cH:8]1>>[CH3:9][c:10]1[cH:11][c:12]([CH2:15][NH:16][C:59]([c:55]2[s:54][c:53]([N:49]3[C:48](=[O:62])[N:47]([CH2:46][c:45]4[cH:44][cH:43][c:42]([F:41])[cH:64][cH:63]4)[CH2:51][CH:50]3[CH3:52])[n:57][c:56]2[CH3:58])=[O:60])[n:13][o:14]1

Participants

5

Reactant 4

HCID 310183-PyridinemethanamineHCID 27763061-(5-Methyl-1,2-oxazol-3-yl)methanamineHCID 666611552-[3-[(4-Fluorophenyl)methyl]-4-methyl-2-oxoimidazolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylic acidHCID 666613802-[3-[(4-Fluorophenyl)methyl]-5-methyl-2-oxoimidazolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylic acid

Product 1

HCID 666615502-[3-[(4-fluorophenyl)methyl]-5-methyl-2-oxoimidazolidin-1-yl]-4-methyl-N-[(5-methyl-1,2-oxazol-3-yl)methyl]-1,3-thiazole-5-carboxamide

Sources & evidence

ORD record
ord-7b2c0fe8579e4d0e9f283721ecf0d09c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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