Acetic Acid → Methyl1-Boc-4-[[(R)-1-phenylethyl]amino]piperidine-3-carboxylate

HRID 2148843Notes

Reaction equation

HRID 2148843 reaction equation
[C:32]([O:33][BH-:34]([O:35][C:36](=[O:37])[CH3:38])[O:39][C:40](=[O:41])[CH3:42])(=[O:43])[CH3:44].[CH3:19][CH:20]([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[NH2:27].[CH3:28][C:29](=[O:30])[OH:31].[Na+:45].[Na+:46].[Na+:47].[O-:48][C:49](=[O:50])[O-:51].[O:1]=[C:2]1[CH:3]([C:15](=[O:16])[O:17][CH3:18])[CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1.[cH:52]1[cH:53][cH:54][cH:55][cH:56][cH:57]1>>[CH:2]1([NH:27][CH:20]([CH3:19])[c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[CH:3]([C:15](=[O:16])[O:17][CH3:18])[CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 241BenzeneHCID 923Sodium ion3×HCID 74081-PhenethylamineHCID 19660Carbonate IonHCID 2724942TriacetoxyborohydrideHCID 112768931-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

Product 1

HCID 68819527Methyl1-Boc-4-[[(R)-1-phenylethyl]amino]piperidine-3-carboxylate

Sources & evidence

ORD record
ord-d797ed7610da47dd99a350765cfcf575
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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