Toluene → Tert-butyl 3-[tert-butyl(dimethyl)silyl]oxy-2-[1-(3-chloro-4-cyano-2-methylanilino)ethyl]pyrrolidine-1-carboxylate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH:21]([CH3:22])[NH2:23])[CH:10]([O:13][Si:14]([CH3:15])([CH3:16])[C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:11][CH2:12]1.[C:35](=[O:36])([O-:37])[O-:38].[CH3:97][c:98]1[cH:99][cH:100][cH:101][cH:102][cH:103]1.[Cl:24][c:25]1[c:26]([C:27]#[N:28])[cH:29][cH:30][c:31]([I:34])[c:32]1[CH3:33].[Cs+:39].[Cs+:40].[O:43]=[C:44]([CH:45]=[CH:46][c:47]1[cH:48][cH:49][cH:50][cH:51][cH:52]1)[CH:53]=[CH:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1.[O:61]=[C:62]([CH:63]=[CH:64][c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1)[CH:71]=[CH:72][c:73]1[cH:74][cH:75][cH:76][cH:77][cH:78]1.[O:79]=[C:80]([CH:81]=[CH:82][c:83]1[cH:84][cH:85][cH:86][cH:87][cH:88]1)[CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1.[Pd:41].[Pd:42]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH:21]([CH3:22])[NH:23][c:31]2[cH:30][cH:29][c:26]([C:27]#[N:28])[c:25]([Cl:24])[c:32]2[CH3:33])[CH:10]([O:13][Si:14]([CH3:15])([CH3:16])[C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:11][CH2:12]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-23e5c3209c5f469d9d2d82d4adfac2af
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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