Dimethyl Sulfoxide → Tert-butyl 5-[6-[(3-methylphenyl)carbamoyl]pyrazin-2-yl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-1-carboxylate

HRID 2149172Notes

Reaction equation

HRID 2149172 reaction equation
[CH3:39][S:40]([CH3:41])=[O:42].[Cl:1][c:2]1[cH:3][n:4][cH:5][c:6]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13]([CH3:17])[cH:14][cH:15][cH:16]2)[n:7]1.[N:18]1([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH:19]2[CH:20]([CH2:21][CH2:22]1)[CH2:23][NH:24][CH2:25]2.[Na+:33].[Na+:34].[O-:35][C:36](=[O:37])[O-:38]>>[c:2]1([N:24]2[CH2:23][CH:20]3[CH:19]([N:18]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:22][CH2:21]3)[CH2:25]2)[cH:3][n:4][cH:5][c:6]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13]([CH3:17])[cH:14][cH:15][cH:16]2)[n:7]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 27554286-Chloro-N-(m-tolyl)pyrazine-2-carboxamideHCID 44474550tert-butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

Product 1

HCID 67265370Tert-butyl 5-[6-[(3-methylphenyl)carbamoyl]pyrazin-2-yl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-1-carboxylate

Sources & evidence

ORD record
ord-06c6d07515b84a918297d5173a998b30
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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