Benzene → 13-methyl-10-(triphenylsilyloxymethyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

HRID 2149403Notes

Reaction equation

HRID 2149403 reaction equation
[OH:1][CH2:2][C:3]12[CH2:4][CH2:5][C:6](=[O:22])[CH:7]=[C:8]1[CH2:9][CH2:10][CH:11]1[CH:12]3[CH2:13][CH2:14][C:15](=[O:21])[C:16]3([CH3:17])[CH2:18][CH2:19][CH:20]21.[c:23]1([Si:29]([Cl:30])([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:24][cH:25][cH:26][cH:27][cH:28]1.[cH:43]1[cH:44][cH:45][n:46][cH:47][cH:48]1.[cH:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1>>[O:1]([CH2:2][C:3]12[CH2:4][CH2:5][C:6](=[O:22])[CH:7]=[C:8]1[CH2:9][CH2:10][CH:11]1[CH:12]3[CH2:13][CH2:14][C:15](=[O:21])[C:16]3([CH3:17])[CH2:18][CH2:19][CH:20]21)[Si:29]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)([c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1

Participants

5

Reactant 4

HCID 241BenzeneHCID 1049PyridineHCID 64581,1',1''-(Chlorosilylidyne)tris(benzene)HCID 52131019-Hydroxy androst-4-ene-3,17-dione

Product 1

HCID 17842108513-methyl-10-(triphenylsilyloxymethyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

Sources & evidence

ORD record
ord-809d23f619d84e0088ef7707739aafa3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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