Hydrochloric Acid → N-[3-chloro-4-(piperidin-1-ylmethyl)phenyl]-3-[2-chloro-4-(trifluoromethyl)phenyl]prop-2-ynamide

HRID 214960Notes

Reaction equation

HRID 214960 reaction equation
[CH3:33][OH:34].[Cl:17][c:18]1[cH:19][c:20]([NH2:31])[cH:21][cH:22][c:23]1[CH2:24][N:25]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1.[Cl:1][c:2]1[c:3]([C:12]#[C:13][C:14](=[O:15])[OH:16])[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[Cl:35][CH2:36][Cl:37].[ClH:32]>>[Cl:1][c:2]1[c:3]([C:12]#[C:13][C:14](=[O:16])[NH:31][c:20]2[cH:19][c:18]([Cl:17])[c:23]([CH2:24][N:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)[cH:22][cH:21]2)[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 287218333-Chloro-4-piperidin-1-ylmethylphenylamineHCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acid

Product 1

HCID 57845708N-[3-chloro-4-(piperidin-1-ylmethyl)phenyl]-3-[2-chloro-4-(trifluoromethyl)phenyl]prop-2-ynamide

Sources & evidence

ORD record
ord-80084c361c2946efb97df4ee24055d0b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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