1-Butanol → 4,4-Diphenyl-1-piperidinepropanol

HRID 2149609Notes

Reaction equation

HRID 2149609 reaction equation
[Br:19][CH2:20][CH2:21][CH2:22][OH:23].[C:24](=[O:25])([O-:26])[O-:27].[CH2:32]([OH:33])[CH2:34][CH2:35][CH3:36].[I-:31].[K+:28].[K+:29].[K+:30].[O:37]1[CH2:38][CH2:39][O:40][CH2:41][CH2:42]1.[c:1]1([C:7]2([c:13]3[cH:14][cH:15][cH:16][cH:17][cH:18]3)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]2([c:13]3[cH:14][cH:15][cH:16][cH:17][cH:18]3)[CH2:8][CH2:9][N:10]([CH2:20][CH2:21][CH2:22][OH:23])[CH2:11][CH2:12]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

8

Reactant 7

HCID 2631-ButanolHCID 813Potassium Cation3×HCID 123083-Bromo-1-propanolHCID 19660Carbonate IonHCID 30165Iodide IonHCID 312751,4-DioxaneHCID 28232394,4-Diphenylpiperidine

Product 1

HCID 104022594,4-Diphenyl-1-piperidinepropanol

Sources & evidence

ORD record
ord-c8642db8e2484ced804ec681528c85b9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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