Acetone → Tert-butyl 3-hydroxy-4-(4-methoxyphenyl)piperidine-1-carboxylate

HRID 214983Notes

Reaction equation

HRID 214983 reaction equation
[C:22](=[O:23])([O-:24])[O-:25].[CH3:28][O:29][S:30]([O:31][CH3:32])(=[O:33])=[O:34].[CH3:35][C:36](=[O:37])[CH3:38].[K+:26].[K+:27].[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([OH:14])[cH:12][cH:13]1>>[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH3:22])[cH:12][cH:13]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 6497Dimethyl SulfateHCID 19660Carbonate IonHCID 21713087(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

Product 1

HCID 45074240Tert-butyl 3-hydroxy-4-(4-methoxyphenyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-3eb0246064f441c0914bb77470bd790d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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