Ethyl 2-bromo-2-cyclopropylacetate → Ethyl 2-[5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-3-prop-2-enylpiperidin-1-yl]-2-cyclopropylacetate

HRID 2150894Notes

Reaction equation

HRID 2150894 reaction equation
[Br:26][CH:27]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[CH:33]1[CH2:34][CH2:35]1.[CH2:1]([CH:2]=[CH2:3])[C:4]1([CH3:25])[C:5](=[O:24])[NH:6][CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1>>[CH2:1]([CH:2]=[CH2:3])[C:4]1([CH3:25])[C:5](=[O:24])[N:6]([CH:27]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[CH:33]2[CH2:34][CH2:35]2)[CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1

Participants

3

Reactant 2

HCID 44222804Ethyl 2-bromo-2-cyclopropylacetateHCID 768348385-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-3-prop-2-enylpiperidin-2-one

Product 1

HCID 76834824Ethyl 2-[5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-3-prop-2-enylpiperidin-1-yl]-2-cyclopropylacetate

Sources & evidence

ORD record
ord-20a1b72f7b3045c89178f62c99005b6e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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