1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → 4-Bromo-6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
Reaction equation
[Br:17][c:18]1[cH:19][c:20]([C:28]([F:29])([F:30])[F:31])[cH:21][c:22]2[nH:23][c:24]([Cl:27])[n:25][c:26]12.[F:1][C:2]([c:3]1[c:4]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[n:5][cH:6][cH:7][cH:8]1)([F:15])[F:16]>>[F:1][C:2]([c:3]1[c:4]([N:9]2[CH2:10][CH2:11][N:12]([c:24]3[nH:23][c:22]4[cH:21][c:20]([C:28]([F:29])([F:30])[F:31])[cH:19][c:18]([Br:17])[c:26]4[n:25]3)[CH2:13][CH2:14]2)[n:5][cH:6][cH:7][cH:8]1)([F:15])[F:16]Participants
3
Sources & evidence
- ORD record
- ord-77c108b53e9f4ef0b048218bf6a4d527
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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