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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2151596Generated: November 4, 2026

Tetrahydrofuran → racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-2'-(3-ethynyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

https://huagongshe.com/reaction/2151596

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantTriethylamineHCID 8471—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
ReactantTrimethylsilylacetyleneHCID 66111—
Reactantracemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-2'-(3-iodophenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dioneHCID 76568101—
Productracemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-2'-(3-ethynyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dioneHCID 76567966—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (4/10)
ORD IDord-7d0537e9eedb44598f95b9b08a894bc3
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (4/10)