Ethanamine, 2,2,2-trifluoro- → 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-{1-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-piperidin-3-yl}-nicotinamide

HRID 2151782Notes

Reaction equation

HRID 2151782 reaction equation
[CH3:1][c:2]1[c:3]([CH2:13][O:14][c:15]2[cH:16][cH:17][c:18]([C:21](=[O:22])[NH:23][CH:24]3[CH2:25][N:26]([CH2:30][C:31](=[O:32])[OH:33])[CH2:27][CH2:28][CH2:29]3)[cH:19][n:20]2)[c:4](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[n:5][o:6]1.[F:34][C:35]([CH2:36][NH2:37])([F:38])[F:39]>>[CH3:1][c:2]1[c:3]([CH2:13][O:14][c:15]2[cH:16][cH:17][c:18]([C:21](=[O:22])[NH:23][CH:24]3[CH2:25][N:26]([CH2:30][C:31](=[O:33])[NH:37][CH2:36][C:35]([F:34])([F:38])[F:39])[CH2:27][CH2:28][CH2:29]3)[cH:19][n:20]2)[c:4](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[n:5][o:6]1

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 57520097(3-{[6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine-3-carbonyl]-amino}-piperidin-1-yl)-acetic acid

Product 1

HCID 684442696-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-{1-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-piperidin-3-yl}-nicotinamide

Sources & evidence

ORD record
ord-b9e86b3a4d2d416c9a595877a37cc9d2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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