4,5,6,7-Tetrahydro-1-benzothiophene-3-carboxylic acid → N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Reaction equation
[NH2:13][c:14]1[cH:15][cH:16][c:17]([N:22]2[CH2:23][CH2:24][CH:25]([OH:28])[CH2:26][CH2:27]2)[c:18]([C:19]#[N:20])[cH:21]1.[s:1]1[c:2]2[c:3]([c:4]([C:6](=[O:7])[OH:8])[cH:5]1)[CH2:9][CH2:10][CH2:11][CH2:12]2>>[s:1]1[c:2]2[c:3]([c:4]([C:6](=[O:8])[NH:13][c:14]3[cH:15][cH:16][c:17]([N:22]4[CH2:23][CH2:24][CH:25]([OH:28])[CH2:26][CH2:27]4)[c:18]([C:19]#[N:20])[cH:21]3)[cH:5]1)[CH2:9][CH2:10][CH2:11][CH2:12]2Participants
3
Sources & evidence
- ORD record
- ord-8bd7bf42b95a4b66a7fbc0312ca93376
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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