Ethanol → tert-butyl N-(4-pyrrolidin-1-ylcyclohexyl)carbamate

HRID 2152139Notes

Reaction equation

HRID 2152139 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][CH2:11][CH:12]([NH2:15])[CH2:13][CH2:14]1.[C:22](=[O:23])([O-:24])[O-:25].[CH2:32]([OH:33])[CH3:34].[Cl:16][CH2:17][CH2:18][CH2:19][CH2:20][Cl:21].[I-:29].[K+:26].[K+:27].[Na+:28].[OH2:30].[OH2:31]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][CH2:11][CH:12]([N:15]2[CH2:17][CH2:18][CH2:19][CH2:20]2)[CH2:13][CH2:14]1

Participants

9

Reactant 8

HCID 702EthanolHCID 813Potassium Cation2×HCID 923Sodium ionHCID 962Water2×HCID 80591,4-DichlorobutaneHCID 19660Carbonate IonHCID 30165Iodide IonHCID 2756050Cis tert-Butyl 4-aminocyclohexylcarbamate

Product 1

HCID 21882609tert-butyl N-(4-pyrrolidin-1-ylcyclohexyl)carbamate

Sources & evidence

ORD record
ord-a94800d415a64d90bdbee4aa1c462e95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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