6-Aminoindole → 5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamine

HRID 2152512Notes

Reaction equation

HRID 2152512 reaction equation
[CH2:1]1[CH2:2][O:3][c:4]2[cH:5][cH:6][c:7]([NH:8][c:9]3[c:10]([F:11])[cH:12][n:13][c:14]([NH:15][c:16]4[cH:17][cH:18][cH:19][c:20]([OH:21])[cH:22]4)[n:23]3)[cH:24][c:25]2[O:26]1.[Cl:27][c:28]1[n:29][cH:30][c:31]([F:42])[c:32]([NH:34][c:35]2[cH:36][c:37]([OH:41])[cH:38][cH:39][cH:40]2)[n:33]1.[NH2:43][c:44]1[cH:45][cH:46][c:47]2[cH:48][cH:49][nH:50][c:51]2[cH:52]1>>[c:28]1([NH:43][c:44]2[cH:45][cH:46][c:47]3[cH:48][cH:49][nH:50][c:51]3[cH:52]2)[n:29][cH:30][c:31]([F:42])[c:32]([NH:34][c:35]2[cH:36][c:37]([OH:41])[cH:38][cH:39][cH:40]2)[n:33]1

Participants

4

Reactant 3

HCID 2560966-AminoindoleHCID 22060334N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamineHCID 220604512-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine

Product 1

HCID 220602765-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-e8ef076d9c1347d4b10ea520121f8efe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…