1-Chloro-4-[(3-chloropropyl)sulfonyl]benzene → 1-[3-[(4-Chlorophenyl)sulfonyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

HRID 2152648Notes

Reaction equation

HRID 2152648 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[CH2:11][CH2:12][CH2:13][Cl:14])[cH:6][cH:7]1.[F:15][c:16]1[cH:17][c:18]([NH:23][CH:24]([CH:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]2)[c:31]2[cH:32][cH:33][c:34]([F:37])[cH:35][cH:36]2)[cH:19][cH:20][c:21]1[F:22]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[CH2:11][CH2:12][CH2:13][N:28]2[CH2:27][CH2:26][CH:25]([CH:24]([NH:23][c:18]3[cH:17][c:16]([F:15])[c:21]([F:22])[cH:20][cH:19]3)[c:31]3[cH:32][cH:33][c:34]([F:37])[cH:35][cH:36]3)[CH2:30][CH2:29]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 167842621-Chloro-4-[(3-chloropropyl)sulfonyl]benzeneHCID 197720314-[[(3,4-Difluorophenyl)amino](4-fluorophenyl)methyl]piperidine

Product 1

HCID 197720271-[3-[(4-Chlorophenyl)sulfonyl]propyl]-N-(3,4-difluorophenyl)-alpha-(4-fluorophenyl)-4-piperidinemethanamine

Sources & evidence

ORD record
ord-3cd2bc285d0b488fbddb360187b658be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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