2-(difluoro(4-fluorophenyl)methyl)-7-fluoro-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine → 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline
Reaction equation
[Cl:29][c:30]1[n:31][c:32]([C:41]([c:42]2[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]2)([F:49])[F:50])[n:33][c:34]2[cH:35][c:36]([F:40])[cH:37][cH:38][c:39]12.[F:1][C:2]([F:3])([c:4]1[cH:5][cH:6][c:7]([F:8])[cH:9][cH:10]1)[c:11]1[n:12][c:13]([NH:14][c:15]2[cH:16][c:17]([CH3:18])[nH:19][n:20]2)[c:21]2[c:22]([cH:23][c:24]([F:25])[cH:26][cH:27]2)[n:28]1>>[CH3:2][c:36]1[cH:35][c:34]2[n:33][c:32]([C:41]([c:42]3[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]3)([F:49])[F:50])[n:31][c:30]([Cl:29])[c:39]2[cH:38][cH:37]1Participants
3
Sources & evidence
- ORD record
- ord-e3fbd0d7b9684fa4a89799c758703143
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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