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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2152941Generated: November 1, 2026

Methanol → 4-(2-Chloro-3,6-difluoro-phenoxy)-6-[6-(4-methylpiperazin-1-yl)-pyridin-3-yl]-1,2,3,4-tetrahydro-[1,8]naphthyridine

https://huagongshe.com/reaction/2152941

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantDichloromethaneHCID 6344—
Reactant2-Chloro-3,6-difluorophenolHCID 2773561—
Reactant6-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]-1,2,3,4-tetrahydro-[1,8]naphthyridin-4-olHCID 57885829—
Product4-(2-Chloro-3,6-difluoro-phenoxy)-6-[6-(4-methylpiperazin-1-yl)-pyridin-3-yl]-1,2,3,4-tetrahydro-[1,8]naphthyridineHCID 46906672—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (4/10)
ORD IDord-00082ed26de348268e4d23d9a5b83446
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (4/10)