HCID 19932873, compound → HCID 19932785, compound

Participants

Reaction Steps

Methyl N-(6-chloro-3-nitro-2-pyridyl)-2-aminoisobutyrate (4.0 g, 14.6 mmol) was hydrogenated in 250 ml of methanol with Raney nickel catalysis under 1 atm of hydrogen. After hydrogen uptake ceased, the catalyst was filtered off with suction, and the filtrate was concentrated and chromatographed on silica gel (ethyl acetate/heptane=1:2). 1.89 g (61%) of the compound of Example 15, of melting point 229° C., were obtained.

Provenance & Evidence