2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-({6-[(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]pyridin-2-yl}amino)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 2153338Notes

Reaction equation

HRID 2153338 reaction equation
[Br:1][c:2]1[n:3][c:4]([CH2:8][c:9]2[o:10][c:11]([CH:14]3[CH2:15][CH2:16]3)[n:12][n:13]2)[cH:5][cH:6][cH:7]1.[NH2:17][c:18]1[s:19][c:20](-[c:26]2[c:27]([F:37])[cH:28][c:29]([C:33]([CH3:34])([CH3:35])[OH:36])[cH:30][c:31]2[F:32])[cH:21][c:22]1[C:23](=[O:24])[NH2:25]>>[c:2]1([NH:17][c:18]2[s:19][c:20](-[c:26]3[c:27]([F:37])[cH:28][c:29]([C:33]([CH3:34])([CH3:35])[OH:36])[cH:30][c:31]3[F:32])[cH:21][c:22]2[C:23](=[O:24])[NH2:25])[n:3][c:4]([CH2:8][c:9]2[o:10][c:11]([CH:14]3[CH2:15][CH2:16]3)[n:12][n:13]2)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595261632-Bromo-6-[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]pyridine

Product 1

HCID 595255772-({6-[(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]pyridin-2-yl}amino)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Sources & evidence

ORD record
ord-559b6f7610f4431480f244419760c342
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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