4-Amino-3-(trifluoromethyl)benzonitrile → 2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-N-(4-cyano-2-trifluoromethyl-phenyl)-2-cyclohexyl-acetamide

HRID 2153377Notes

Reaction equation

HRID 2153377 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([C:14](=[O:15])[OH:16])[CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[cH:23][c:24]([F:28])[c:25]([F:27])[cH:26]3)[cH:6][cH:7]1.[NH2:29][c:30]1[c:31]([C:38]([F:39])([F:40])[F:41])[cH:32][c:33]([C:34]#[N:35])[cH:36][cH:37]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([C:14](=[O:15])[NH:29][c:30]2[c:31]([C:38]([F:39])([F:40])[F:41])[cH:32][c:33]([C:34]#[N:35])[cH:36][cH:37]2)[CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[cH:23][c:24]([F:28])[c:25]([F:27])[cH:26]3)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 27794884-Amino-3-(trifluoromethyl)benzonitrileHCID 66619321[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid

Product 1

HCID 866320262-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-N-(4-cyano-2-trifluoromethyl-phenyl)-2-cyclohexyl-acetamide

Sources & evidence

ORD record
ord-e7d0526a3bff48d89b4c942a520ab8af
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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