HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → (2RS)-1-(Isopropoxycarbonyl)-2-methyl-1,2-dihydro-1,4,5,7-tetraazanaphthalene-3(4H)-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | HCID 19932782 | HCID 19932782 | — |
| Product | (2RS)-1-(Isopropoxycarbonyl)-2-methyl-1,2-dihydro-1,4,5,7-tetraazanaphthalene-3(4H)-thione | HCID 19932819 | 28% |
Reaction Steps
100 mg of (2RS)-1-(isopropoxycarbonyl)-2-methyl-1,2-dihydro-1,4,5,7-tetraazanaphthalen-3(4H)-one from Example 24 were reacted with Lawesson's reagent in analogy to Example 20. The crude product after concentration was chromatographed (silica gel; ethyl acetate/heptane=1:1). 30 mg (28%) of the desired compound, of melting point 203°-204° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424311 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-cb7cb858867743fd95b620cbded84999 |
| Source note | uspto-grants-1995_06 |