7-Bromo-4-(4-fluorophenyl)-chromen-2-one → (+)-7-([5-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxyethyl)-1,3-thiazol-2-yl]thio}-4-(4-fluorophenyl)-2H-chromen-2-one

HRID 2153573Notes

Reaction equation

HRID 2153573 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6](-[c:13]3[cH:14][cH:15][c:16]([F:19])[cH:17][cH:18]3)[cH:7][c:8](=[O:12])[o:9][c:10]2[cH:11]1.[CH:20]1([C:23]([C:24]([F:25])([F:26])[F:27])([OH:28])[c:29]2[cH:30][n:31][c:32]([SH:34])[s:33]2)[CH2:21][CH2:22]1>>[c:2]1([S:34][c:32]2[n:31][cH:30][c:29]([C:23]([CH:20]3[CH2:21][CH2:22]3)([C:24]([F:25])([F:26])[F:27])[OH:28])[s:33]2)[cH:3][cH:4][c:5]2[c:6](-[c:13]3[cH:14][cH:15][c:16]([F:19])[cH:17][cH:18]3)[cH:7][c:8](=[O:12])[o:9][c:10]2[cH:11]1

Participants

3

Reactant 2

HCID 233702437-Bromo-4-(4-fluorophenyl)-chromen-2-oneHCID 178519846HCID 178519846, compound

Product 1

HCID 11363891(+)-7-([5-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxyethyl)-1,3-thiazol-2-yl]thio}-4-(4-fluorophenyl)-2H-chromen-2-one

Sources & evidence

ORD record
ord-d4499d2013424da986a87ea6581413b5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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