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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2154854Generated: November 4, 2026

Formaldehyde → Methyl 2-[1-[2-[tert-butyl(diphenyl)silyl]oxy-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]-3-hydroxypropanoate

https://huagongshe.com/reaction/2154854

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantNitrogenHCID 947—
ReactantDiisopropylamineHCID 7912—
ReactantTetrahydrofuranHCID 8028—
ReactantLithium ionHCID 28486—
ReactantDiisopropylamideHCID 5062348—
ReactantMethyl 2-[1-[2-[tert-butyl(diphenyl)silyl]oxy-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetateHCID 76834392—
ReactantButyllithiumHCID 178418339—
ProductMethyl 2-[1-[2-[tert-butyl(diphenyl)silyl]oxy-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]-3-hydroxypropanoateHCID 76834556—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (4/10)
ORD IDord-d096b52f5d314f47ac0bef60f906c837
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (4/10)